A Pilot Study to Evaluate the Efficacy of Class IV Lasers on Nonhealing Neuroischemic Diabetic Foot Ulcers in Patients With Type 2 Diabetes
The laser used in this pilot study is the first example of a high-powered device with four wavelengths concomitantly acting on multiple metabolic processes that accelerate the wound healing: stimulation of cytochrome-C oxidase, an increase in angiogenesis, and improvement in blood perfusion (5).
Adding class 4 laser therapy resulted in significantly improved outcomes.
Taking into consideration the limitations of this proof-of-concept study, our findings indicate that laser therapy delivered by a class IV laser can significantly impact the healing process of neuroischemic DFUs refractory to standard treatment. Randomized controlled clinical trials with this new laser device in larger populations are required to confirm our results.